Lexapro vs. Paxil: Differences and Similarities

Anxiety and depression are common mental health disorders in the United States and many people who suffer from one disorder often also suffer from both.

In fact, about one half of the people diagnosed with depression also receive diagnoses of an anxiety disorder, according to the Anxiety & Depression Association of America.

Though anxiety and depression can have a negative impact on overall quality of life, treatment options are available, including talk therapy, mindfulness, and prescription medication.

Prescription antidepressants help millions of people find relief from symptoms of anxiety, depression, and other mental health conditions every year. 

Selective serotonin reuptake inhibitors (SSRIs) are often considered the first-line medication treatment for depression and anxiety because of their safety and efficacy.

Paxil (paroxetine) and Lexapro (escitalopram) are two SSRI medications that can be prescribed to treat anxiety and depression. 

When researching the differences between Paxil, Lexapro, and other antidepressant medications, it’s important to remember that it may take some time to find the right prescription for your symptoms.

In this article, I’ll describe the differences and similarities between these two medications as well as their uses, side effects and precautions.

What are the differences between Paxil and Lexapro?

Paxil and Lexapro are FDA-approved SSRIs antidepressant medications that can help to improve symptoms of anxiety and depression by increasing the levels of serotonin in your brain.

Serotonin helps to regulate mood, sleep, and other bodily functions.

Below is a chart of some of the main differences between the two medications:

Conditions Treated

Paxil and Lexapro can be prescribed to treat:

*  Off-label means it can be used for the condition but is not an official indication

Which is More Effective?

Paxil and Lexapro have both been approved by the FDA for the safe and effective treatment of clinical depression, anxiety disorders, and other conditions.

There are several findings from clinical trials and studies that compare the two medications; however, these reviews only provide general information on the medications’ effects.  

While these findings are important, it’s equally important to remember that the effectiveness of one medication will vary depending on the individual and their circumstances, including their medical history, genetics, and more. One of the primary factors that influence the effectiveness of the medication is the condition you are being treated for. 

As we discussed earlier, each medication treats a specific set of conditions; there is no one medication that treats everything.  Because of this, it is important that you have discussed all of your symptoms, thoughts, and feelings with your provider to ensure you receive the correct diagnosis and treatment.  

Potential Side Effects

Taking Paxil or Lexapro can cause some side effects. The most common side effects are usually mild and resolve on their own as your body adjusts to the medication.

But if you experience any severe or long-lasting side effects, be sure to reach out to your provider as soon as possible.

Drug Interactions

Before starting a new medication it’s important to tell your provider about any medications or supplements you’re currently taking, as some may interact with Lexapro or Paxil to cause adverse reactions, including serotonin syndrome.

Serotonin syndrome symptoms include agitation, confusion, and an irregular heartbeat. 

This list does not include all of the possible drug interactions however, these are some of the more common ones.

Warnings for Paxil and Lexapro

In addition to the risk of serotonin syndrome, Paxil and Lexapro carry other warnings and precautions. 

Some rare but severe side effects are possible when taking Lexapro and Paxil, including suicidal ideation or suicidal thoughts. 

To ensure you’re taking the medication safely, it’s important to disclose any existing medical conditions, medications or supplements you’re currently taking, and whether or not you’re pregnant or plan to become pregnant with your provider.

Alcohol consumption should also be limited while taking these medications.  

When to See a Healthcare Provider

It’s a good idea to reach out to your provider if you experience any persistent or worsening signs and symptoms of anxiety, depression, or another mental health condition.

Talking with your provider can help you determine whether or not an SSRI like Lexapro or Paxil is right for you. 

Do not stop taking the medication without speaking to a healthcare provider.

If you’ve already started taking an SSRI, be sure to reach out to your provider and go to the nearest healthcare facility immediately if you experience any uncontrollable thoughts, major mood changes, hallucinations, suicidal thoughts, or thoughts of hurting yourself or someone else. 

Though rare, you should seek immediate medical attention if you experience any severe side effects, such as:

• Severe dizziness
• Hives, or a red or purple rash with blistering or peeling
• Itching or swelling, particularly of the mouth, face, or throat
• Difficulty breathing
• Seizure
• Irregular heartbeat 
• Chest pain
• Confusion
• Altered level of consciousness 
• Fainting

How K Health Can Help

Think you might need a prescription for Lexapro (escitalopram) or a prescription for Paxil (paroxetine)?

K Health has clinicians standing by 24/7 to evaluate your symptoms and determine which prescription is right for you.

Get started with our free assessment, which will tell you in minutes if treatment could be a good fit. If yes, we’ll connect you right to a clinician who can prescribe medication and have it shipped right to your door.